AustralieFrV1, Main, Exploration, bibRecord, 008C89

History of Hypertension and Eplerenone in Patients With Acute Myocardial Infarction Complicated by Heart Failure. Commentary

Identifieur interne : 008C89 ( Main/Exploration ); précédent : 008C88; suivant : 008C90

History of Hypertension and Eplerenone in Patients With Acute Myocardial Infarction Complicated by Heart Failure. Commentary

Auteurs : Luis M. Ruilope [Espagne] ; Bertram Pitt [États-Unis] ; Ali Ahmed [États-Unis] ; Thomas E. Love [États-Unis] ; Henry Krum [Australie] ; Jose Nicolau [Brésil] ; José S. Cardoso [Portugal] ; Alexander Parkhomenko [Ukraine] ; Michael Aschermann [République tchèque] ; Ramon Corbalan [Chili] ; Henry Solomon [États-Unis] ; Harry Shi [États-Unis] ; Faiez Zannad [France]

Source :

Hypertension : (Dallas, Tex. 1979) [ 0194-911X ] ; 2008.

RBID : Pascal:08-0404858

Descripteurs français

Pascal (Inist)
- Hypertension artérielle, Insuffisance cardiaque, Pathologie de l'appareil circulatoire, Eplérénone, Homme, Complication, Morbidité, Mortalité, Antihypertenseur.
Wicri :
- topic : Homme, Mortalité.

English descriptors

KwdEn :
- Antihypertensive agent, Cardiovascular disease, Complication, Eplerenone, Heart failure, Human, Hypertension, Morbidity, Mortality.

Abstract

-In the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (n=6632), eplerenone-associated reduction in all-cause mortality was significantly greater in those with a history of hypertension (Hx-HTN). There were 4007 patients with Hx-HTN (eplerenone: n=1983) and 2625 patients without Hx-HTN (eplerenone: n=1336). Propensity scores for eplerenone use, separately calculated for patients with and without Hx-HTN, were used to assemble matched cohorts of 1838 and 1176 pairs of patients. In patients with Hx-HTN, all-cause mortality occurred in 18% of patients treated with placebo (rate, 1430/10 000 person-years) and 14% of patients treated with eplerenone (rate, 1058/10 000 person-years) during 2350 and 2457 years of follow-up, respectively (hazard ratio [HR]: 0.71; 95% CI: 0.59 to 0.85; P<0.0001). Composite end point of cardiovascular hospitalization or cardiovascular mortality occurred in 33% of placebo-treated patients (3029/10 000 person-years) and 28% of eplerenone-treated patients (2438/10 000 person-years) with Hx-HTN (HR: 0.82; 95% CI: 0.72 to 0.94; P=0.003). In patients without Hx-HTN, eplerenone reduced heart failure hospitalization (HR: 73; 95% CI: 0.55 to 0.97; P=0.028) but had no effect on mortality (HR: 0.91; 95% CI: 0.72 to 1.15; P=0.435) or on the composite end point (HR: 0.91; 95% CI: 0.76 to 1.10; P=0.331). Eplerenone should, therefore, be prescribed to all of the post-acute myocardial infarction patients with reduced left ventricular ejection fraction and heart failure regardless of Hx-HTN.

Affiliations:

Australie, Brésil, Chili, Espagne, France, Portugal, République tchèque, Ukraine, États-Unis
Bohême centrale, Communauté de Madrid, Ohio, État de São Paulo
Madrid, Prague, São Paulo

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 003359
to stream PascalFrancis, to step Curation: 002C93
to stream PascalFrancis, to step Checkpoint: 003185
to stream Main, to step Merge: 009599
to stream Main, to step Curation: 008C89

Le document en format XML

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<author><name sortKey="Zannad, Faiez" sort="Zannad, Faiez" uniqKey="Zannad F" first="Faiez" last="Zannad">Faiez Zannad</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antihypertensive agent</term>
<term>Cardiovascular disease</term>
<term>Complication</term>
<term>Eplerenone</term>
<term>Heart failure</term>
<term>Human</term>
<term>Hypertension</term>
<term>Morbidity</term>
<term>Mortality</term>
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<term>Insuffisance cardiaque</term>
<term>Pathologie de l'appareil circulatoire</term>
<term>Eplérénone</term>
<term>Homme</term>
<term>Complication</term>
<term>Morbidité</term>
<term>Mortalité</term>
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<front><div type="abstract" xml:lang="en">-In the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (n=6632), eplerenone-associated reduction in all-cause mortality was significantly greater in those with a history of hypertension (Hx-HTN). There were 4007 patients with Hx-HTN (eplerenone: n=1983) and 2625 patients without Hx-HTN (eplerenone: n=1336). Propensity scores for eplerenone use, separately calculated for patients with and without Hx-HTN, were used to assemble matched cohorts of 1838 and 1176 pairs of patients. In patients with Hx-HTN, all-cause mortality occurred in 18% of patients treated with placebo (rate, 1430/10 000 person-years) and 14% of patients treated with eplerenone (rate, 1058/10 000 person-years) during 2350 and 2457 years of follow-up, respectively (hazard ratio [HR]: 0.71; 95% CI: 0.59 to 0.85; P<0.0001). Composite end point of cardiovascular hospitalization or cardiovascular mortality occurred in 33% of placebo-treated patients (3029/10 000 person-years) and 28% of eplerenone-treated patients (2438/10 000 person-years) with Hx-HTN (HR: 0.82; 95% CI: 0.72 to 0.94; P=0.003). In patients without Hx-HTN, eplerenone reduced heart failure hospitalization (HR: 73; 95% CI: 0.55 to 0.97; P=0.028) but had no effect on mortality (HR: 0.91; 95% CI: 0.72 to 1.15; P=0.435) or on the composite end point (HR: 0.91; 95% CI: 0.76 to 1.10; P=0.331). Eplerenone should, therefore, be prescribed to all of the post-acute myocardial infarction patients with reduced left ventricular ejection fraction and heart failure regardless of Hx-HTN.</div>
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<li>Chili</li>
<li>Espagne</li>
<li>France</li>
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<li>République tchèque</li>
<li>Ukraine</li>
<li>États-Unis</li>
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<region><li>Bohême centrale</li>
<li>Communauté de Madrid</li>
<li>Ohio</li>
<li>État de São Paulo</li>
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<tree><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Ruilope, Luis M" sort="Ruilope, Luis M" uniqKey="Ruilope L" first="Luis M." last="Ruilope">Luis M. Ruilope</name>
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<country name="Australie"><noRegion><name sortKey="Krum, Henry" sort="Krum, Henry" uniqKey="Krum H" first="Henry" last="Krum">Henry Krum</name>
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<country name="Brésil"><region name="État de São Paulo"><name sortKey="Nicolau, Jose" sort="Nicolau, Jose" uniqKey="Nicolau J" first="Jose" last="Nicolau">Jose Nicolau</name>
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<country name="Portugal"><noRegion><name sortKey="Cardoso, Jose S" sort="Cardoso, Jose S" uniqKey="Cardoso J" first="José S." last="Cardoso">José S. Cardoso</name>
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</country>
<country name="Ukraine"><noRegion><name sortKey="Parkhomenko, Alexander" sort="Parkhomenko, Alexander" uniqKey="Parkhomenko A" first="Alexander" last="Parkhomenko">Alexander Parkhomenko</name>
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<country name="République tchèque"><region name="Bohême centrale"><name sortKey="Aschermann, Michael" sort="Aschermann, Michael" uniqKey="Aschermann M" first="Michael" last="Aschermann">Michael Aschermann</name>
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<country name="Chili"><noRegion><name sortKey="Corbalan, Ramon" sort="Corbalan, Ramon" uniqKey="Corbalan R" first="Ramon" last="Corbalan">Ramon Corbalan</name>
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<country name="France"><noRegion><name sortKey="Zannad, Faiez" sort="Zannad, Faiez" uniqKey="Zannad F" first="Faiez" last="Zannad">Faiez Zannad</name>
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</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 008C89 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 008C89 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:08-0404858
   |texte=   History of Hypertension and Eplerenone in Patients With Acute Myocardial Infarction Complicated by Heart Failure. Commentary
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les relations entre la France et l'Australie

History of Hypertension and Eplerenone in Patients With Acute Myocardial Infarction Complicated by Heart Failure. Commentary

History of Hypertension and Eplerenone in Patients With Acute Myocardial Infarction Complicated by Heart Failure. Commentary

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri